(n): the act of hindering or obstructing or impeding
(n): a situation or condition that is complex or confused
(n): the general state of things; the combination of circumstances at a given time
(n): any disease or disorder that occurs during the course of (or because of) another disease
(n): an impairment of health or a condition of abnormal functioning
(n): a development that complicates a situation
(n): a recent event that has some relevance for the present situation
(n): puzzling complexity
(n): the quality of being intricate and compounded