(n): poor physical condition; being out of shape or out of condition (as from a life of ease and luxury)
(n): advantage given to a competitor to equalize chances of winning
(n): the quality of having a superior or more favorable position
(n): something immaterial that interferes with or delays action or progress
(n): a factor causing trouble in achieving a positive result or tending to produce a negative result
(v): injure permanently
(v): cause injuries or bodily harm to
(v): attempt to forecast the winner (especially in a horse race) and assign odds for or against a contestant
(v): influence in an unfair way
(v): put at a disadvantage
(v): put at a disadvantage; hinder, harm
Classic contronym: advantage vs. disadvantage.